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Interferon-a therapy led to remission of disease and a substantial reduction of the prednisolone requirement in two patients who had attained incomplete remission with cyclophosphamide or methotrexate.The third patient's condition stabilized,and the fourth patient maintained remission.During interferon-a therapy,the blood eosinophil count in all patients decreased in a dose-dependent manner and paralleled the extent of clinical disease and disease activity.Interferon-a may be an effective treatment for the Churg-Strauss syndrome.It seems to exert its effect primarily by producing a dose-dependent decrease in the blood eosinophil count. |
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